https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11267 Wed 24 Jul 2013 22:28:44 AEST ]]> Th22 cells form a distinct Th lineage from Th17 cells in vitro with unique transcriptional properties and Tbet-dependent Th1 plasticity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33753 Wed 13 Feb 2019 09:58:18 AEDT ]]> Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43341 Thu 15 Sep 2022 15:18:39 AEST ]]> A critical role for the CXCL3/CXCL5/CXCR2 neutrophilic chemotactic axis in the regulation of type 2 responses in a model of rhinoviral-induced asthma exacerbation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40298 Thu 11 May 2023 14:03:27 AEST ]]> MicroRNA-487b is a negative regulator of macrophage activation by targeting IL-33 production https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30084 Thu 03 Feb 2022 12:18:07 AEDT ]]> Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19859 Thu 01 Aug 2019 17:32:15 AEST ]]> Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5196 Thu 01 Aug 2019 17:32:00 AEST ]]> Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7312 Sat 24 Mar 2018 08:34:00 AEDT ]]> Pulmonary eosinophils and their role in immunopathologic responses to formalin-inactivated pneumonia virus of mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7272 Sat 24 Mar 2018 08:33:52 AEDT ]]> Placental cytokine expression covaries with maternal asthma severity and fetal sex https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7273 Sat 24 Mar 2018 08:33:51 AEDT ]]> Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-γ and TLR4/MyD88 pathways https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7244 Sat 24 Mar 2018 08:33:46 AEDT ]]> Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1061 Sat 24 Mar 2018 08:32:13 AEDT ]]> Antibody binding to individual short consensus repeats of decay-accelerating factor enhances enterovirus cell attachment and infectivity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2788 Sat 24 Mar 2018 08:27:07 AEDT ]]> Pneumococcal components induce regulatory T cells that attenuate the development of allergic airways disease by deviating and suppressing the immune response to allergen https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15999 Sat 24 Mar 2018 08:19:32 AEDT ]]> Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13276 + T cell cytokine production was abrogated. The adoptive transfer of TLR7-sufficient, but not TLR7-deficient pDC to TLR7 gene-deleted mice recapitulated the antiviral responses observed in wild-type mice and promoted virus clearance. In summary, TLR7-mediated signaling by pDC is required for appropriate innate responses to acute pneumovirus infection. It is conceivable that as-yet–unidentified defects in the TLR7 signaling pathway may be associated with elevated levels of RSV-associated morbidity and mortality among otherwise healthy human infants.]]> Sat 24 Mar 2018 08:15:16 AEDT ]]> NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11486 Sat 24 Mar 2018 08:10:26 AEDT ]]> IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11518 Sat 24 Mar 2018 08:10:22 AEDT ]]> TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5132 Sat 24 Mar 2018 07:49:44 AEDT ]]> Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5135 Sat 24 Mar 2018 07:49:39 AEDT ]]> The IL-3/IL-5/GM-CSF common β receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5180 Sat 24 Mar 2018 07:47:49 AEDT ]]> Regulatory T cells prevent inducible BALT formation by dampening neutrophilic inflammation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22279 Sat 24 Mar 2018 07:17:42 AEDT ]]> Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22277 Lcp2 that reduced the amount of wild-type SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees. Mutant mice produced excessive amounts of proinflammatory cytokines, autoantibodies, and IgE, revealing that simple quantitative reductions of SLP-76 were sufficient to trigger immune dysregulation. This allele reveals a dose-sensitive threshold for SLP-76 in the balance of immunity and immune dysregulation, a common disturbance of atypical clinical immune deficiencies.]]> Sat 24 Mar 2018 07:17:41 AEDT ]]> CCL7 and IRF-7 mediate hallmark inflammatory and IFN responses following rhinovirus 1B infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22160 Sat 24 Mar 2018 07:14:59 AEDT ]]> TNF-α and macrophages are critical for respiratory syncytial virus-induced exacerbations in a mouse model of allergic airways disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24758 Sat 24 Mar 2018 07:14:04 AEDT ]]> Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22106 Streptococcus pneumoniae induces Tregs that have potential to be harnessed therapeutically for asthma. In this study, mouse models of AAD were used to identify the S. pneumoniae components that have suppressive properties, and the mechanisms underlying suppression were investigated. We tested the suppressive capacity of type-3-polysaccharide (T3P), isolated cell walls, pneumolysoid (Ply) and CpG. When coadministered, T3P + Ply suppressed the development of: eosinophilic inflammation, Th2 cytokine release, mucus hypersecretion, and AHR. Importantly, T3P + Ply also attenuated features of AAD when administered during established disease. We show that NKT cells contributed to the development of AAD and also were suppressed by T3P + Ply treatment. Furthermore, adoptive transfer of NKT cells induced AHR, which also could be reversed by T3P + Ply. T3P + Ply-induced Tregs were essential for the suppression of NKT cells and AAD, which was demonstrated by Treg depletion. Collectively, our results show that the S. pneumoniae components T3P + Ply suppress AAD through the induction of Tregs that blocked the activity of NKT cells. These data suggest that S. pneumoniae components may have potential as a therapeutic strategy for the suppression of allergic asthma through the induction of Tregs and suppression of NKT cells.]]> Sat 24 Mar 2018 07:10:19 AEDT ]]> Identification of IFN-γ and IL-27 as critical regulators of respiratory syncytial virus-induced exacerbation of allergic airways disease in a mouse model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33087 Fri 24 Aug 2018 16:25:53 AEST ]]> Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34903 Csf1r-deficient rats by homologous recombination in embryonic stem cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of peripheral blood monocytes, microglia in the brain, epidermal Langerhans cells, splenic marginal zone macrophages, bone-associated macrophages and osteoclasts, and peritoneal macrophages. Macrophages of splenic red pulp, liver, lung, and gut were less affected. The pleiotropic impacts of the loss of macrophages on development of multiple organ systems in rats were distinct from those reported in mice. Csf1r-/- rats survived well into adulthood with postnatal growth retardation, distinct skeletal and bone marrow abnormalities, infertility, and loss of visceral adipose tissue. Gene expression analysis in spleen revealed selective loss of transcripts associated with the marginal zone and, in brain regions, the loss of known and candidate novel microglia-associated transcripts. Despite the complete absence of microglia, there was little overt phenotype in brain, aside from reduced myelination and increased expression of dopamine receptor-associated transcripts in striatum. The results highlight the redundant and nonredundant functions of CSF1R signaling and of macrophages in development, organogenesis, and homeostasis.]]> Fri 21 Jan 2022 09:33:47 AEDT ]]> 4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53870 Fri 19 Jan 2024 12:39:17 AEDT ]]>